Is myocardial fibrosis in patients with non-ischemic dilated cardiomyopathy associated with the whole-heart myocardial mechanics?

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Non-ischemic dilated cardiomyopathy (NIDCM) is a severe form primary myocardial disease related with progressive heart failure (HF) and poor prognosis. In patients NIDCM, fibrosis (MF) associated to adverse cardiovascular outcomes should be evaluated quickly in each case NIDCM [1,2]. Purpose To evaluate the relationships between whole-heart strain parameters presence late gadolinium enhancement (LGE) prospective cohort patients. Methods The study group consisted 101 who were referred for magnetic resonance (CMR) speckle tracking echocardiography examination. We analyzed MF by LGE, (both ventricles atria) mechanics tracking. All underwent comprehensive clinical evaluation, laboratory test assessment, electrocardiogram, Holter monitoring. exclusion criteria ischemic coronary disease, valvular chronic kidney (eGFR <30 ml/min/1.73 m2), under age 18, echocardiographic or CMR image quality, inflammatory previous pulmonary embolism, peripartum toxic damage. Results was divided into two groups according fibrosis. worse parameters. Both atria more MF. strongest detected mechanical left side (left ventricle ejection fraction (LVEF) (r=0.662, 25 p<0.001), global circumferential (LV GCS) (r=-0.609, longitudinal GLS) (r=-0.586, atrial reservoir (LASr) (r=0.588, p<0.001). Logistic regression analysis revealed that last three mentioned independently Conclusions are patients‘ LV GLS, GCS, LARs best 2D prognosticate